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Contents
Common use
Zofran (ondansetron) is an antiemetic medication used to prevent and treat nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. It works by blocking serotonin (5-HT3) receptors in the brain and digestive tract, which play a key role in vomiting reflex.
Zofran is commonly prescribed for both adults and children undergoing cancer treatments or anesthesia.
Dosage and direction
Zofran is available in tablets, orally disintegrating tablets (ODT), and injectable forms.
A typical adult dose for chemotherapy-induced nausea is 8 mg taken 30 minutes before treatment, followed by 8 mg every 8-12 hours for 1-2 days.
For postoperative nausea, a single dose of 4 mg may be given before or after surgery.
Take the medicine exactly as your doctor prescribes. Do not chew or break ODT tablets - let them dissolve on the tongue.
Precautions
Before taking Zofran, tell your doctor if you have:
Liver disease
Irregular heart rhythm (especially long QT syndrome)
Electrolyte imbalance (low potassium or magnesium)
A history of allergic reaction to similar meds
Avoid driving or operating machinery until you know how the drug affects you. It may cause dizzyness or lightheadedness in some people.
Contraindications
Do not use Zofran if you:
Are allergic to ondansetron or any of its ingredients
Are taking apomorphine
The safety in pregnancy is not fully established, so consult your doctor if pregnant or breastfeeding.
Possible side effects
Common side effects:
Headache
Fatigue
Constipation
Dizzyness
Less common but serious:
Irregular heartbeat
Vision changes
Serotonin syndrome (if combined with other serotonergic drugs)
Seek immediate help if you notice swelling, rash, or breathing difficuties after taking the medicine.
Drug interactions
Zofran may interact with:
SSRIs and SNRIs (may increase risk of serotonin syndrome)
Tramadol
Antiarrhythmic drugs
Seizure medications
Apomorphine (contraindicated)
Always share your full medication list with your doctor.
Missed dose
If you miss a dose and still feel nauseous, take it as soon as you remmember. If it's almost time for the next dose, skip the missed one. Do not double the dose.
Overdose
Overdose symptoms may include vision loss (temporary), severe constipation, or irregular heartbeat. In case of suspected overdose, contact emergency services immediately.
Storage
Store Zofran at room temperature between 68F-77F (20C-25C). Protect from moisture and light. Keep out of reach of children.
U.S. Sale and Prescription Policy
Zofran is an FDA-approved prescription medication in the United States. It is not available over-the-counter.
Patients must have a valid prescription from a licensed healthcare provider. The drug is regulated due to potential side effects, especially in those with cardiac issues.
Purchasing from unauthorized sources online is unsafe and may lead to counterfeit drugs or legal issues.
Disclaimer
This information is provided for educational purposes and does not replace professional medical advice. Always follow the directions of your doctor or pharmacist. We are not responsble for misuse or adverse effects caused by inappropriate use.