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Contents
Common use
Naltrexone is an opioid antagonist used to support recovery from alcohol and opioid dependence. It blocks the euphoric and sedative effects of opioids and reduces the desire to drink or use.
It is not a cure for addiction, but when combined with counseling or behavioral therapy, it can significantly improve success rates.
Dosage and direction
Take naltrexone exactly as prescribed. For opioid dependence, the typical oral dose is 50 mg once daily. For alcohol dependence, the same dose is often used, but doctors may adjust it based on treatment response.
A full detox from opioids is required you must be opioid-free for 7-10 days before starting naltrexone to avoid precipitated withdrawal.
Do not drink alcohol or use opiates while on this medication. Tablets can be taken with or without food, with water.
Precautions
Inform your doctor if you have:
Liver problems
Kidney disease
History of depression or suicidial thoughts
Bleeding disorders
Avoid driving or operating heavy machinery if you feel dizzy or sleepy. Regular blood tests may be needed to monitor liver enzymes during long-term use.
Contraindications
Do not take naltrexone if you:
Are currently using opioids or are in withdrawal
Have acute hepatitis or severe liver failure
Are allergic to naltrexone
Pregnant or breastfeading women should only use this medication under medical guidance.
Possible side effects
Common side effects:
Nausea
Headache
Fatigue or drowziness
Insomnia
Less common but serious:
Liver damage (yellowing skin/eyes)
Depression or mood changes
Injection site reactions (if using injectable naltrexone)
Contact your doctor if you notice severe symptoms or suicidal ideation.
Drug interactions
Naltrexone may interact with:
Opioid pain medications (e.g. morphine, oxycodone)
Cough/cold medicines containing codeine
Diarrhea medications (like loperamide)
Using opioids while on naltrexone can be dangerous and ineffective. Always carry a medical ID card showing you are using this drug.
Missed dose
If you miss a dose, take it as soon as you remember. If it's nearly time for the next one, skip the missed dose. Do not take two at once.
Overdose
Although naltrexone is not typically associated with overdose, high doses may lead to liver toxicity or severe nausea. Seek immedaite help if you feel unwell after taking too much.
Storage
Store at room temperature (68F-77F / 20C-25C), away from excess heat or moisture. Do not freeze. Keep away from children and pets.
U.S. Sale and Prescription Policy
In the United States, naltrexone is FDA-approved for opioid and alcohol dependence and is available by prescription only.
The medication is dispensed in oral form (tablets) or long-acting injectable (Vivitrol). It must be prescribed and monitored by a licensed healthcare provider.
Buying or using naltrexone without a valid U.S. prescription is not permitted and may carry serious risks due to detox requirements and liver impact.
Disclaimer
This information is provided for educational purposes only and is not medical advice. Always consult your doctor before starting, stopping, or changing medications.