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Contents
Common use
Motilium (domperidone) is a dopamine antagonist that works on the upper digestive tract to increase the movement of food through the stomach and intestines. It is mainly used to treat:
Nausea and vomiting
Bloating and gastric discomfort
Gastroparesis (slow stomach emptying)
Motilium may also be prescribed off-label to help stimulate breast milk production in some cases under medical supervision.
Dosage and direction
Take Motilium as prescribed by your doctor. The typical dose is 10 mg taken 15-30 minutes before meals, up to 3 times per day. It should not be used in high doses or for long periods without supervision.
Swallow the tablet whole with a glass of water. Do not crush or chew.
Precautions
Before using Motilium, tell your doctor if you have:
Liver disease
Heart rhythm disorders (e.g., QT prolongation)
Electrolyte imbalances
Intestinal bleeding or obstruction
Motilium should not be used in infants or children under 12 years unless directed by a doctor.
Avoid alcohol while taking this medicine, as it may increase side effects like drowziness.
Contraindications
Do not use Motilium if you:
Are allergic to domperidone
Have moderate to severe liver impairment
Have heart condtions that may affect rhythm
Are taking certain antifungal or antibiotic medications that inhibit CYP3A4
Possible side effects
Common side effects:
Dry mouth
Abdominal cramps
Headache
Drowsiness or dizziness
Less common or serious effects:
Breast tenderness or milk discharge
Irregular heartbeat
Seizures (rare)
Allergic reactions such as rash or swelling
Stop using and contact your doctor if any unusual symptons occur.
Drug interactions
Motilium can interact with:
Antifungals (ketoconazole, itraconazole)
Macrolide antibiotics (erythromycin, clarithromycin)
Medications affecting heart rhythm
Antidepressants like fluoxetine or sertraline
Avoid combining with other dopamine antagonists unless instructed.
Missed dose
Take the missed dose as soon as you remember. If it's near the time of your next dose, skip the missed one. Do not double the dose.
Overdose
Overdose symptoms include confusion, agitation, uncontrolled muscle movements, and heart arrhythmias. Seek emergency medical attention right away.
Storage
Store Motilium at room temperature (68F-77F / 20C-25C), away from moisture and light. Keep in a dry place, out of reach of children and pets.
U.S. Sale and Prescription Policy
Motilium (domperidone) is not FDA-approved for general use in the United States due to potential cardiac risks. It is only available through special investigational access programs for patients with severe gastrointestinal motility disorders.
Importation and online purchase of Motilium without U.S. regulatory approval or prescription is considered unlawful and may pose health risks.
Use of domperidone in the U.S. should always be done under a doctor's strict supervision and in accordance with FDA guidance.
Disclaimer
This text is provided for informational purposes only and does not substitute professional medical advice. Always follow your healthcare provider's directions and read patient leaflets before use.